Extended Data Fig. 10 |. DNA breaks within DCC gene body.

a, Genome browser screenshots within DCC gene displaying END-seq profiles as normalized read density (RPM) for KM12-shWRN cells treated DMSO (NT), doxycycline (shWRN) for 72 h, or MUS81–EME1 in situ. b, Zoom-in view of region including exons 6 and 7 of DCC gene, containing two (TA)_n repeats displaying END-seq peaks. The highlighted sequences below were extracted from long read sequencing reads in KM12 cells. The (TA)_n repeat in intron 7 is where Vogelstein and colleagues previously detected an insertion.