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. Author manuscript; available in PMC: 2022 Mar 11.
Published in final edited form as: Nature. 2020 Sep 30;586(7828):292–298. doi: 10.1038/s41586-020-2769-8

Extended Data Fig. 3 |. WRN depletion induces DNA breakage in common fragile sites and palindromic TA-rich repeats in MSI cells.

Extended Data Fig. 3 |

a, Genome browser screenshot displaying END-seq profiles of common fragile sites FRA16D, FRA3B, FRA10B and FRA7I as normalized read density (RPM) for KM12-shWRN cells treated with DMSO (NT) or doxycycline (shWRN) for 72 h. The number of uninterrupted (TA)n repeat units in the hg19 reference genome at DSB sites is indicated. b, Genome browser screenshot displaying END-seq profiles of PATRRs on chromosomes 11 and 22 as normalized read density (RPM) for KM12-shWRN cells treated with DMSO (NT) or doxycycline (shWRN) for 72 h.