TABLE 2.
Comparison of risk factors between the primary endpoint group and the event‐free group
| Characteristics | Primary endpoint (n = 13) | Event free (n = 170) | p‐value | Univariate analysis HR (95% CI) | p‐value | Multivariate analysis HR (95% CI) | p‐value |
|---|---|---|---|---|---|---|---|
| Age, years | 70 (66.5, 81.0) | 69.0 (61.0,77.0) | .41 | 1.02 (0.98–1.08) | .31 | 1.02 (0.98–1.08) | .27 |
| Male | 8 (84.6) | 118 (69.4) | .25 | 1.06 (1.03–1.10) | .001 | 1.07 (1.03–1.11) | .001 |
| Hypertension | 8 (61.5) | 125 (73.5) | .35 | 0.56 (0.18–1.72) | .31 | ||
| Dyslipidemia | 8 (61.5) | 101 (59.4) | .88 | 1.04 (0.34–3.19) | .94 | ||
| Diabetes mellitus | 7 (53.8) | 75 (44.1) | .69 | 1.43 (0.48–4.26) | .52 | ||
| ICD | 4 (30.8) | 12 (7.1) | .022 | 6.79 (1.98–23.26) | .002 | ||
| RRT | 2 (15.3) | 17 (10) | .289 | 2.53 (0.53–11.95) | .24 | ||
| eGFR, (ml/min/1.73 m2) | 32.5 ± 24.3 | 42.8 ± 18 | .028 | 0.97 (0.94–0.99) | .014 | 0.96 (0.93–1.00) | .055 |
| LVEF, % | 38.0 (29.1, 52.9) | 56.9 (41.0, 69.4) | .023 | 0.95 (0.92–0.99) | .004 | 0.98 (0.94–1.03) | .44 |
| LVM, g | 205.0 (135.5, 236.4) | 180.5 (147.8, 224.4) | .81 | 1.00 (0.99–1.02) | .98 | ||
| LVMI, g/m2 | 108.7 ± 35.9 | 106.5 ± 37.6 | .88 | 1.003 (0.98–1.029) | .79 | ||
| BNP, pg/dl | 393.9 (220.0, 853.1) | 174.3 (55.7, 335.1) | .005 | ||||
| NYHA I, II | 8 (61.5) | 152 (89.4) | Ref | Ref | |||
| NYHA III, IV | 5 (38.4) | 18 (10.5) | .003 | 3.94 (1.29–12.06) | .016 | ||
| β‐blocker | 11 (92.3) | 123 (72.3) | .34 | ||||
| RAS inhibitor | 8 (61.5) | 116 (68.2) | .62 | ||||
| Amiodarone | 4 (23.4) | 23 (13.5) | .096 | ||||
| w‐LPs | 10 (76.9) | 69 (40.6) | .011 | 6.04 (1.40–22.3) | .007 | 3.18 (0.72–13.99) | .13 |
| HRT | 8 (61.5) | 68 (40.5) | .13 | 3.01 (0.98–9.25) | .54 | ||
| NSVT | 7 (53.8) | 20 (11.8) | <.001 | 8.72 (2.80–26.5) | <.001 | 10.41 (2.81–38.51) | <.0001 |
Values are expressed as n (%), mean ± standard deviation, median (interquartile range), or hazard ratio (95% confidence interval).
Abbreviations: BNP, brain natriuretic peptide; CHF, chronic heart failure; CI, confidence intervals; DCM, dilated cardiomyopathy; GFR, glomerular filtration rate; HHD, hypertensive heart disease; HRT, heart rate turbulence; ICD, implantable cardioverter defibrillator; IHD, ischemic heart disease; LVDd, left ventricular dimension diameter; LVEF, left ventricular ejection fraction; LVM, left ventricular mass; LVMI, left ventricular mass index; NSVT, nonsustained ventricular tachycardia; RAS, renin–angiotensin–aldosterone system; ref, reference; RRT, renal replacement therapy; w‐LP, worst value of ambulatory‐based late potentials.