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Inhibition of hemozoin-initiated hematin polymerization at pH 4.8
| Compound | IC50 (μM) (mean ± SD) |
|---|---|
| Chloroquine | 80 ± 20 |
| Primaquine | >2,500 |
| WR 249420 | 27 ± 3 |
| WR 251855 | 54 ± 5 |
| WR 254715 | 100 ± 3 |
| WR 238605 | 16 ± 2 |
| WR 255740 | 700 ± 80 |
| WR 255821 | 98 ± 8 |
| WR 259841 | 630 ± 35 |
| WR 266848 | 44 ± 6 |
| WR 268379 | 41 ± 6 |
| WR 268499 | 140 ± 26 |
| WR 268648 | 61 ± 24 |
| WR 268658 | 25 ± 1 |
| WR 242511 | 32 ± 6 |
