Table 1.
Three independent SNPs in a multivariate Cox proportional hazards regression analysis with adjustment for other covariates and 41 previously published SNPs for NSCLC in the PLCO Trial
| Variables | Category | Frequency | HR (95% CI)a | P a | HR (95% CI)b | P b |
|---|---|---|---|---|---|---|
| Age | Continuous | 1,185 | 1.03 (1.02–1.05) | <0.0001 | 1.05 (1.03–1.06) | <0.0001 |
| Sex | Male | 698 | 1.00 | 1.00 | ||
| Female | 487 | 0.79 (0.67–0.92) | 0.002 | 0.70 (0.59–0.83) | <0.0001 | |
| Smoking status | Never | 115 | 1.00 | 1.00 | ||
| Current | 423 | 1.73 (1.28–2.32) | 0.0003 | 2.10 (1.53–2.87) | <0.0001 | |
| Former | 647 | 1.70 (1.29–2.34) | 0.0002 | 2.06 (1.53–2.76) | <0.0001 | |
| Histology | Adenocarcinoma | 577 | 1.00 | 1.00 | ||
| Squamous cell | 285 | 1.16 (0.96–1.40) | 0.114 | 1.18 (0.96–1.44) | 0.109 | |
| others | 323 | 1.27 (1.08–1.51) | 0.005 | 1.42 (1.18–1.71) | 0.0003 | |
| Tumor stage | I-IIIA | 655 | 1.00 | 1.00 | ||
| IIIB-IV | 528 | 2.93 (2.41–3.55) | <0.0001 | 3.91 (3.16–4.85) | <0.0001 | |
| Chemotherapy | No | 639 | 1.00 | 1.00 | ||
| Yes | 538 | 0.55 (0.46–0.66) | <0.0001 | 0.52 (0.43–0.63) | <0.0001 | |
| Radiotherapy | No | 762 | 1.00 | 1.00 | ||
| Yes | 415 | 0.94 (0.79–1.10) | 0.418 | 1.12 (0.94–1.34) | 0.211 | |
| Surgery | No | 637 | 1.00 | 1.00 | ||
| Yes | 540 | 0.20 (0.16–0.26) | <0.0001 | 0.20 (0.15–0.26) | <0.0001 | |
| CHEK1 rs76744140 | TT/TC/CC | 1,028/152/5 | 1.29 (1.06–1.56) | 0.009 | 1.35 (1.09–1.66) | 0.006 |
| PRIM2 rs6939623 | GG/GT/TT | 981/199/5 | 1.35 (1.14–1.59) | 0.001 | 1.24 (1.03–1.50) | 0.021 |
| CDK6 rs113181986 | GG/GC/CC | 1,052/131/2 | 0.76 (0.60–0.97) | 0.025 | 0.77 (0.60–1.00) | 0.046 |
Abbreviations: SNP: single-nucleotide polymorphisms; NSCLC, non-small cell lung cancer; PLCO, the Prostate, Lung, Colorectal and Ovarian cancer screening trial; HLCS, Harvard Lung Cancer Susceptibility Study; HR: hazards ratio; CI: confidence interval
Adjusted for age, sex, tumor stage, histology, smoking status, chemotherapy, radiotherapy, surgery, and PC1, PC2, PC3, PC4.
Other 41 published SNPs were included for further adjustment:rs779901, rs3806116, rs199731120, rs10794069, rs1732793, rs225390, rs3788142, rs73049469, rs35970494, rs225388, rs7553295, rs1279590, rs73534533, rs677844, rs4978754, rs1555195, rs11660748, rs73440898, rs13040574, rs469783, rs36071574, rs7242481, rs1049493, rs1801701, rs35859010, rs1833970, rs254315, rs425904, rs35385129, rs4487030, rs60571065, rs13213007, rs115613985, rs9673682, rs2011404, rs7867814, rs2547235, rs4733124, rs11225211, rs11787670, rs67715745