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. 2022 Mar 11;8(10):eabh1419. doi: 10.1126/sciadv.abh1419

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Fig. 4. — (A) Effect of growth on BBs due to loading of 5-FU. The drug prevented the growth of BB. FUBB (red) showed up to 12 hours of prolonged lag phase, whereas in EBB (blue) it was around 6 hours. 5-FU also caused a reduction of growth of L. reuteri (green), and the extent was higher than that of BB. (B) Lactic acid production (signature of L. reuteri metabolic activity), although it did not alter much due to 5-FU loading. (C) Release study of 5-FU after loading on BB in SGF at pH 2.0 (red), SIF at pH 6.4 (green), and SIF at pH 7.4 (blue). After the initial blast in SIF delayed blast in SGF (between 30 min and 1 hour), a sustained-release pattern was observed in all formulations.