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. 2022 Mar 9;42(10):2065–2079. doi: 10.1523/JNEUROSCI.0923-20.2021

Figure 1.

Figure 1.

Intracerebroventricular administration of the MEK inhibitor U0126 promotes functional recovery after ICH in mice. A, ICH and sham animals received intracerebroventricular injections of 12 µg U0126 or vehicle at 2 h after ICH surgery, and the functional recovery (adhesive tape removal and corner task) was assessed up to 7 d after ICH. Values show mean ± SD for adhesive tape removal and median for corner task; *p < 0.05 versus baseline, #p < 0.05 versus ICH+vehicle. B, The indirect hematoma volume and hemispheric swelling (edema) were measured at 24 h after ICH. The values show the mean ± SD for hematoma volume and the median for hemispheric swelling. C, D, Neuronal cell survival was assessed using Fluoro-jade B staining in the perihematoma (C) and NeuN immunofluorescence in the cortex and striatum (D) at 24 h after ICH. Scale bar: 100 µm. Mean ± SD is shown. *p < 0.05. For exact p values, refer to Extended Data Figure 1-3.