Table 1.
Motor cortical EEG measurements during cortical SWA and ACT in Q175 and WT micea
| Figure/text | Measurement | Brain state | Genotype | n (mice/EEG epochs) | Median [IQ range] (mV2) | p (comparison; test) |
|---|---|---|---|---|---|---|
| 2B, C | 0.1-1.5 Hz EEG power | SWA | WT | 12/64 | 2.8e-03 [2.0e-03-4.9e-03] | p = 0.70 (SWA: WT vs Q175; MWU) |
| Q175 | 11/72 | 3.0e-03 [1.9e-03-4.1e-03] | ||||
| 2D, E | 20-60 Hz EEG power | SWA | WT | 12/64 | 1.0e-06 [6.7e-07-1.5e-06] | p = 1.3 (SWA: WT vs Q175; MWU) |
| Q175 | 11/72 | 1.1e-06 [6.2e-07-1.7e-06) | ||||
| text | 4-8 Hz EEG power | SWA | WT | 12/64 | 6.1e-05 [3.5e-05-1.4e-04] | p = 0.062 (SWA: WT vs Q175; MWU) |
| Q175 | 11/72 | 4.8e-05 [3.0e-05-9.2e-05] | ||||
| text | 8-12 Hz EEG power | SWA | WT | 12/64 | 1.4e-05 [8.7e-06-2.3e-05] | p = 0.19 (SWA: WT vs Q175; MWU) |
| Q175 | 11/72 | 1.2e-05 [5.8e-06-1.9e-05] | ||||
| text | 12-40 Hz EEG power | SWA | WT | 12/64 | 2.7e-06 [1.8e-06-3.7e-06] | p = 0.60 (SWA: WT vs Q175; MWU) |
| Q175 | 11/72 | 2.4e-06 [1.5e-06-3.3e-06] | ||||
| text | 40-100 Hz EEG power | SWA | WT | 12/64 | 3.3e-07 [2.4e-07-4.6e-07] | p = 0.11 (SWA: WT vs Q175; MWU) |
| Q175 | 11/72 | 4.1e-07 [2.5e-07-6.8e-07] | ||||
| 2B, C | 0.1-1.5 Hz EEG power | ACT | WT | 12/64 | 2.5e-04 [1.4e-04-6.4e-04] | p = 1.7e-11 (WT: SWA vs ACT; WSR) |
| Q175 | 11/72 | 2.9e-04 [1.6e-04-5.0e-04] | p = 6.8e-13 (Q175: SWA vs ACT; WSR) | |||
| p = 0.76 (ACT: WT vs Q175; MWU) | ||||||
| 2D, E | 20-60 Hz EEG power | ACT | WT | 12/64 | 1.3e-06 [1.1e-06-2.0e-06] | p = 3.1e-06 (WT: SWA vs ACT; WSR) |
| Q175 | 11/72 | 1.4e-06 [1.1e-06-1.8e-06] | p = 7.2e-06 (Q175: SWA vs ACT; WSR) | |||
| p = 0.72 (ACT: WT vs Q175; MWU) | ||||||
| text | 4-8 Hz EEG power | ACT | WT | 12/64 | 4.6e-05 [2.6e-05-6.3e-05] | p = 3.0e-03 (WT: SWA vs ACT; WSR) |
| Q175 | 11/72 | 2.8e-05 [1.8e-05-5.6e-05] | p = 9.0e-05 (Q175: SWA vs ACT; WSR) | |||
| p = 0.083 (ACT: WT vs Q175; MWU) | ||||||
| text | 8-12 Hz EEG power | ACT | WT | 12/64 | 9.0e-06 [5.2e-06-1.6e-05] | p = 4.0e-04 (WT: SWA vs ACT; WSR) |
| Q175 | 11/72 | 8.1e-06 [4.7e-06-1.2e-05] | p = 0.058 (Q175: SWA vs ACT; WSR) | |||
| p = 0.32 (ACT: WT vs Q175; MWU) | ||||||
| text | 12-40 Hz EEG power | ACT | WT | 12/64 | 2.3e-06 [1.7e-06-3.8e-06] | p = 0.87 (WT: SWA vs ACT; WSR) |
| Q175 | 11/72 | 2.3e-06 [1.7e-06-2.9e-06] | p = 1.30 (Q175: SWA vs ACT; WSR) | |||
| p = 1.1 (ACT: WT vs Q175; MWU) | ||||||
| text | 40-100 Hz EEG power | ACT | WT | 12/64 | 5.2e-07 [3.8e-07-7.6e-07] | p = 6.4e-10 (WT: SWA vs ACT; WSR) |
| Q175 | 11/72 | 5.4e-07 [4.0e-07-8.0e-07] | p = 1.2e-03 (Q175: SWA vs ACT; WSR) | |||
| p = 0.59 (ACT: WT vs Q175; MWU) |
aOscillatory activities in the motor cortex of Q175 and WT mice were similar. The power of low-frequency oscillations declined and the power of high-frequency oscillations increased following the transition from cortical SWA to ACT in both Q175 and WT mice.