Table 1. Comparison of neuropathological features in Cmtm5-, Cnp-, and Plp-mutant mice.

Neuropathological features in Cmtm5 cKO,Cnp^-/-, and Plp^-/Y mice and key references are given. APP, amyloid precursor protein.

Feature	Cmtm5 mutants	Cnp mutants	Plp mutants
Myelinated axons (%)	Normal	Reduced	Reduced
Myelin thickness	Normal	Trend to thinner myelin	Normal-appearing
Myelin structure	Normal	Inner-tongue swellings, myelin outfoldings	Lamella splittings, myelin outfoldings
Axonopathy	Early onset, progressive	Early onset, progressive	Early onset, progressive
Modified by WldS	Reduction of pathology	No effect	No effect
APP+ axonal swellings	Late onset	Early onset	Early onset
Microgliosis	Late onset	Early onset	Early onset
Astrogliosis	Late onset	Early onset	Early onset
References	This study	Edgar et al., 2009; Lappe-Siefke et al., 2003; Patzig et al., 2016; Rasband et al., 2005	Edgar et al., 2004; Griffiths et al., 1998; Klugmann et al., 1997; Patzig et al., 2016