Skip to main content
. Author manuscript; available in PMC: 2022 Mar 11.
Published in final edited form as: Sci Transl Med. 2021 May 19;13(594):eabc1739. doi: 10.1126/scitranslmed.abc1739

Figure 3. Predicted variant impact on IQ of ASD patient pairs with different de novo missense variants in the same candidate gene.

Figure 3.

Pairs of patients with ASD affected by different de novo missense variants in the same prioritized gene were identified across the 398 prioritized genes (n = 28). Within each pair, the patient with the higher variant evolutionary action score was determined. Full-scale IQ scores were compared between the higher and lower evolutionary action groups using a paired t-test. Correctly prioritized pairs are shown linked by a solid black line; incorrectly prioritized pairs are shown linked by a dashed grey line.