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. 2022 Mar 4;2022:3613319. doi: 10.1155/2022/3613319

Figure 3.

Figure 3

BMSCs can donate additional mitochondria to NPCs with mitochondrial dysfunction. (a, b) Representative confocal images and histogram analysis showing that CFSE+ NPCs pretreated with 0, 2 μM, 5 μM, and 10 μM rot received mitochondria from neighboring MitoTracker Red+ NPCs and the mitochondrial transfer rate. (c, d) Representative confocal images and histogram showing that CFSE+ NPCs pretreated with 0, 2 μM, 5 μM, and 10 μM rot received mitochondria from neighboring MitoTracker Red+ BMSCs and the mitochondrial transfer rate. Green arrowheads: NPCs; red arrowheads: BMSCs; white arrowheads: mitochondria. Scale bar, 20 μm. Means ± SD, n = 6. ∗P < 0.05, ∗∗∗P < 0.001, and ∗∗∗∗P < 0.0001, ns: not significant vs. the control group. BMSCs: bone marrow mesenchymal stem cells; NPCs: nucleus pulposus cells; rot: rotenone.