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. 2022 Mar 4;2022:3613319. doi: 10.1155/2022/3613319

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Copyright © 2022 Fan Yang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Miro1 knockdown decreases the efficiency of mitochondrial functional rescue in NPCs. (a) Flow cytometric analysis of mitochondrial membrane potential in NPCs cocultured with BMSCmiro^Lo. (b) Histogram showing the mitochondrial membrane potential. Means ± SD, n = 4. (c) Flow cytometric analysis of ROS levels in NPCs cocultured with BMSCmiro^Lo. (d) Relative levels of intracellular ROS. Means ± SD, n = 4. (e–g) Histogram showing the levels of ATP, ADP, and ADP/ATP in NPCs cocultured with BMSCmiro^Lo. (h–j) Histogram showing the levels of NAD+, NADH, and NADH/NAD+ in NPCs cocultured with BMSCmiro^Lo. Means ± SD, n = 6. ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001, and ^∗∗∗∗P < 0.0001. BMSCs: bone marrow mesenchymal stem cells; BMSCmiro^Cc: control adenovirus-transfected BMSCs; BMSCmiro^Lo: BMSCs transfected with adenovirus carrying Rhot1 shRNA; NPCs: nucleus pulposus cells; rot: rotenone.