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. 2022 Mar 12;43(5):1071–1083. doi: 10.1007/s00246-022-02827-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Influence of pubertal stage on NT-proBNP levels in the LIFE Child Study cohort. Box-plots represent the 25th and 75th percentiles (boxes) and 50th percentile (mid line). NT-proBNP levels were higher in girls than in boys with an increasing effect in advancing puberty and dropped significantly in both genders again with an increasing effect in ongoing puberty until stage 4, from where only levels in males decreased further. NT-proBNP levels were determined with ECLIA, Cobas Roche (n = 2537)