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. Author manuscript; available in PMC: 2023 May 19.
Published in final edited form as: J Toxicol Environ Health A. 2022 Jan 19;85(10):397–413. doi: 10.1080/15287394.2022.2026849

Table 2.

Arcuate expression of neuropeptides and receptors from ERαKO males and females

Males Females
Gene Control-LFD Control-HFD OPFR-LFD OPFR-HFD Control-LFD Control-HFD OPFR-LFD OPFR-HFD
Agrp 1.07 ± 0.19 0.64 ± 0.19 0.82 ± 0.15 0.99 ± 0.19 1.04 ± 0.14 0.88 ± 0.14 1.42 ± 0.29 0.73 ± 0.06A
Cart 1.08 ± 0.19 0.93 ± 0.11 1.00 ± 0.11 1.42 ± 0.25 1.01 ± 0.08 1.08 ± 0.07 0.86 ± 0.09 1.07 ± 0.06
Npy 1.03 ± 0.11 0.64 ± 0.12 1.64 ± 0.28 0.95 ± 0.12 1.02 ± 0.11 0.85 ± 0.10 1.51 ± 0.24 1.11 ± 0.13
Pomc 1.10 ± 0.24 0.92 ± 0.14 0.93 ± 0.05A 1.66 ± 0.14a 1.02 ± 0.10 0.96 ± 0.11 0.85 ± 0.06 0.93 ± 0.05
Ghsr 1.08 ± 0.17 0.90 ± 0.13 1.14 ± 0.18 1.14 ± 0.08 1.02 ± 0.09 0.94 ± 0.08 1.18 ± 0.14 1.15 ± 0.09
Insr 1.05 ± 0.14 1.44 ± 0.15 1.54 ± 0.17 1.65 ± 0.15 1.01 ± 0.06 1.21 ± 0.12 1.67 ± 0.17 1.38 ± 0.24
Lepr 1.04 ± 0.13 0.99 ± 0.11 1.54 ± 0.23 1.25 ± 0.06 1.01 ± 0.06 1.00 ± 0.08 1.37 ± 0.13 1.15 ± 0.10
Pparg 1.03 ± 0.11 0.83 ± 0.18 0.83 ± 0.09 0.98 ± 0.13 1.08 ± 0.22 1.30 ± 0.13 2.72 ± 0.85 1.70 ± 0.22

Arcuate expression of neuropeptides and receptors. Data were analyzed by a two-way ANOVA with post-hoc Newman-Keuls multiple comparisons test. Uppercase letters denote diet effects within exposure group and lowercase letters denote OPFR effects within diet group. All data were normalized to Control-LFD within each sex. Data (n = 5-6 per group) are presented as mean ± SEM. Significant overall ANOVA effects are as follows. Male: Npy F(1,18)Diet= 8.457, P < .05, F(1,18)OPFR= 6.150, P < .05; Pomc F(1,18)Diet*OPFR= 7.517, P < .05; Insr F(1,18)-OPFR= 4.915, P < .05); Lepr F(1,18)OPFR= 5.668, P < .05. Female: Agrp F(1,19)Diet= 5.422, P < .05; Npy F(1,19)OPFR= 5.462, P < .05; Pparg F(1,19)OPFR= 4.612, P < .05; Insr F(1,19)OPFR= 5.859, P < .05; Lepr F(1,19)OPFR= 6.596, P < .05.