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Aminoglycoside dosing characteristics for 78 patients with pneumonia caused by gram-negative bacteria
| Variable | Before IPM (n = 78) | After IPM (n = 60) |
|---|---|---|
| Aminoglycoside dose (mg)a | 105 (90–140) | 230 (175–320) |
| Dosing interval (no. [%] of patients) | ||
| 6 h | 1 (1) | 0 (0) |
| 8 h | 16 (21) | 15 (19) |
| 12 h | 49 (63) | 37 (48) |
| 18 h | 4 (5) | 8 (10) |
| 24 h | 8 (10) | 17 (22) |
| 36 h | 0 (0) | 1 (1) |
| Cmax (μg/ml)a | 5.3 (3.9–6.3) | 6.7 (5.2–7.6) |
| Cmin (μg/ml)a | 0.6 (0.3–1.1) | 0.8 (0.5–1.1) |
Values are medians (interquartile ranges).
