TABLE 3.
Aminoglycoside pharmacokinetic and pharmacodynamic variables for 78 patients with pneumonia caused by gram-negative bacteria
| Variable | Median (interquartile range) |
|---|---|
| Aminoglycoside CL (ml/min/1.73 m2) | 71.5 (50.4–91.3) |
| Aminoglycoside half-life (h) | 3.5 (2.6–5.0) |
| AUC0–24 (μg · h/ml) | 52.2 (34.5–77.5) |
| AUC0–48 (μg · h/ml) | 104.9 (81.9–142.9) |
| AUC0–72 (μg · h/ml) | 168.8 (130.7–219.0) |
| AUC24 (μg · h/ml) | 56.5 (42.9–75.3) |
| First Cmax/MIC | 3.6 (1.4–6.2) |
| First Cmin/MIC | 0.3 (0.2–0.7) |
| Second Cmax/MIC | 3.7 (1.9–6.9) |
| Second Cmin/MIC | 0.4 (0.2–0.8) |
| AUC0–24/MIC (SIT−1 · 24 h) | 38.7 (13.9–67.2) |
| AUC0–48/MIC (SIT−1 · 24 h) | 77.0 (25.8–131.2) |
| AUC0–72/MIC (SIT−1 · 24 h) | 113.6 (40.8–199.9) |
| AUC24/MIC (SIT−1 · 24 h) | 38.9 (14.6–60.0) |