Table 2.
Summary of participant baseline characteristics
| Characteristic | Normal (n = 8) | Mild impairment (n = 8) | Moderate impairment (n = 8) | Severe impairment (n = 5) | Total (N = 29) |
|---|---|---|---|---|---|
| Age (years) | 56.6 (3.66) | 59.0 (7.27) | 63.1 (4.88) | 60.4 (11.08) | 59.7 (6.81) |
| Sex, n (%) | |||||
| Male | 5 (62.5%) | 5 (62.5%) | 3 (37.5%) | 4 (80.0%) | 17 (58.6%) |
| Female | 3 (37.5%) | 3 (37.5%) | 5 (62.5%) | 1 (20.0%) | 12 (41.1%) |
| Race, n (%) | |||||
| White | 5 (62.5%) | 7 (87.5%) | 8 (100.0%) | 3 (60.0%) | 23 (79.3%) |
| Black | 3 (37.5%) | 0 | 0 | 2 (40.0%) | 5 (17.2%) |
| Asian | 0 | 1 (12.5%) | 0 | 0 | 1 (3.4%) |
| Weight (kg) | 83.8 (8.78) | 73.5 (5.91) | 88.7 (12.33) | 84.2 (2.53) | 82.4 (10.10) |
| Body mass index (kg/m2) | 28.1 (2.07) | 25.6 (2.50) | 31.0 (4.00) | 30.3 (1.49) | 28.6 (3.42) |
| Absolute eGFR (mL/min) | 114.7 (12.08) | 75.1 (5.73) | 42.5 (10.74) | 20.3 (7.18) | NA |
| CLcr (mL/min) | 118.4 (14.53) | 79.8 (8.93) | 54.0 (15.35) | 25.3 (7.31) | NA |
Data are mean (standard deviation), unless otherwise noted
CLcr was estimated based on the Cockcroft–Gault equation
CLcr creatinine clearance, eGFR estimated glomerular filtration rate, NA not applicable