Table 5.

Descriptive summary of urine lorlatinib pharmacokinetic parameters by renal function group

Parameter (unit)	Normal function (n = 8)	Mild impairment (n = 8)	Moderate impairment (n = 8)	Severe impairment (n = 5)
Ae (mg)	0.9441 ± 0.38542	1.218 ± 0.42974	0.8379 ± 0.54929	0.7836 ± 0.36385
Ae (%)	0.9441 ± 0.38542	1.218 ± 0.42974	0.8379 ± 0.54929	0.7836 ± 0.36385
CLR (L/h)	0.1095 (42)	0.1382 (50)	0.08199 (55)	0.06872 (45)

n  number of participants contributing to the summary statistics

Data are geometric mean (geometric % coefficient of variation) for CL_R except arithmetic mean ± standard deviation for Ae and Ae (%)

CL_R for one participant in the normal renal function group was calculated based on Ae₉₆ and AUC_last since this participant’s last quantifiable plasma concentration was measured at 96 h

Ae₉₆ cumulative amount of drug recovered unchanged in urine from time 0 to 96 h post dose, Ae cumulative amount of drug recovered unchanged in urine from time 0 to 120 h post dose, CL_R renal clearance