Table 2.

Summary of nicotine pharmacokinetic parameters

Product	Nicotine/pouch (mg)	Cmax (ng/mL)	AUC0–6h (ng·h/mL)	Tmax (min)	T1/2 (h)a
Cigarette	N/A	13.9 (82.7) n = 34	25.2 (60.1) n = 34	7 (3,20) n = 34	2.3 (0.49) n = 32
Lyft NP	10	17.1 (24.0) n = 35	53.7 (27.2) n = 35	60 (7,76) n = 35	2.2 (0.48) n = 35
Zyn NP	10	11.9 (26.8) n = 35	35.8 (30.6) n = 35	65 (45,75) n = 35	2.8 (3.29) n = 34
Nordic Spirit NP	9	18.4 (30.1) n = 35	52.8 (30.5) n = 35	62 (10,120) n = 35	2.2 (0.42) n = 33
On! NP	6	17.5 (43.8) n = 35	46.9 (44.2) n = 35	65 (45,75) n = 35	2.2 (0.31) n = 34
Skruf NP	8	13.0 (20.2) n = 35	39.0 (26.4) n = 35	60 (3,75) n = 35	2.2 (0.42) n = 34

Data are presented as geometric mean (geometric coefficient of variation) for C_max and AUC_0–6h; median (min, max) for T_max; and mean (SD) for T_1/2

N/A not applicable, C_max maximum plasma nicotine concentration, AUC_0–6h area under the plasma nicotine concentration–time curve between 0 and 6 h, T_max time of maximum plasma nicotine concentration, T_1/2 half-life of plasma nicotine decay, n number of subjects

^aEight study periods were excluded for T_1/2 due to the lack of a linear fit in the elimination phase