Table 3.
Statistical comparisons for nicotine pharmacokinetic parameters
| Comparison | p value | ||
|---|---|---|---|
| Reference product | Comparator product | AUC0–6h | Cmax |
| Cigarette | Lyft NP (10 mg) | 0.0001 | 0.0084 |
| Lyft NP (10 mg) | Zyn NP (10 mg) | 0.0001 | 0.0001 |
| Lyft NP (10 mg) | Nordic Spirit NP (9 mg) | 0.8257 | 0.3086 |
| Lyft NP (10 mg) | On! NP (6 mg) | 0.0265 | 0.7498 |
| Lyft NP (10 mg) | Skruf NP (8 mg) | 0.0001 | 0.0005 |
Data are unadjusted two-sided p values for the comparison
Cmax maximum plasma nicotine concentration, AUC0–6h area under the plasma nicotine concentration–time curve between 0 and 6 h