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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Hypertension. 2022 Jan 7;79(4):761–772. doi: 10.1161/HYPERTENSIONAHA.121.18584

Table 2.

DNA methylation regions associated 24-hour average, daytime, or nighttime blood pressures following adjustment for age, sex, and BMI.

MR Information 24h BP
BP chr start end α p adjusted p Prop.cov Prop.MR
SBP 24h avg 13 25,745,246 25,745,301 −4.1 1.04E-06 0.026 12.7% 8.1%
19 47,569,729 47,569,789 19.5 1.34E-06 0.026 8.3% 7.7%
DBP 24h avg 19 47,569,729 47,569,789 12.7 1.80E-06 0.034 6.9% 7.6%
5 145,725,340 145,725,376 −5.4 1.55E-06 0.034 6.7% 8.0%
PP 24h avg 9 139,317,613 139,317,697 1.9 4.92E-07 0.019 7.0% 8.3%
11 44,330,609 44,330,643 −5.6 1.86E-06 0.035 7.3% 8.4%
13 25,745,246 25,745,301 −1.9 3.39E-06 0.043 9.4% 7.6%
MAP 24h avg 19 47,569,729 47,569,789 15.0 8.63E-07 0.033 7.8% 8.0%
5 145,725,340 145,725,376 −6.1 2.36E-06 0.045 7.7% 7.7%
PP day 9 139,317,613 139,317,697 1.9 3.53E-07 0.013 7.2% 8.5%
11 44,330,609 44,330,643 −5.6 1.11E-06 0.021 7.4% 8.8%
13 65,723,859 65,723,946 9.3 1.97E-06 0.025 5.6% 7.6%
16 88,512,223 88,512,278 3.0 3.31E-06 0.032 6.7% 7.1%
13 25,745,246 25,745,301 −1.9 5.06E-06 0.036 9.5% 7.4%
2 133,031,534 133,031,592 5.0 5.65E-06 0.036 5.7% 7.1%
16 2,229,956 2,230,045 11.1 6.97E-06 0.038 4.1% 7.6%
10 88,295,236 88,295,267 −6.6 1.21E-05 0.049 6.6% 6.9%
10 134,276,268 134,276,333 6.5 1.04E-05 0.049 6.4% 7.0%
9 139,404,808 139,404,851 7.1 1.29E-05 0.049 6.7% 6.5%
DBP night 5 145,725,340 145,725,376 −6.2 5.84E-07 0.022 4.3% 9.2%
19 47,569,729 47,569,789 14.1 2.11E-06 0.040 4.7% 8.2%
PP night 7 158,789,546 158,789,867 4.9 3.88E-07 0.015 4.4% 9.4%
11 44,330,609 44,330,643 −6.2 2.61E-06 0.050 5.0% 8.8%
MAP night 19 47,569,729 47,569,789 16.1 1.70E-06 0.032 5.7% 8.3%
5 145,725,340 145,725,376 −6.8 1.30E-06 0.032 5.1% 8.6%

BP: blood pressure, chr: chromosome, pos: position, MR: methylation region, BMI: body mass index, SBP: systolic blood pressure, DBP: diastolic blood pressure, PP: pulse pressure, MAP: mean arterial pressure, avg: average, α: directionality and effect size estimate, Prop.cov: percentage of BP variance explained by the adjusted covariates; Prop.MR: percentage of BP variance explained by the identified MR.