Table 2.

HbA_1c, glycated albumin, fructosamine, and long-term glycemic variability stratified by small vessel disease findings in brain MRI in individuals with type 1 diabetes

	Cerebral small vessel disease			Cerebral microbleeds			White matter hyperintensities
	Presence (n = 66)	Absence (n = 123)	p	Presence (n = 45)	Absence (n = 144)	p	Presence (n = 32)	Absence (n = 157)	p
HbA1c, %, (mmol/mol)	8.2 (7.6–8.9), (66.0 [59.8–73.3])	8.0 (7.3–8.8), (64.0 [56.0–73.0])	0.259	8.2 (7.6–8.9), (66.0 [60.0–73.0])	8.1 (7.4–8.8), (65.0 [57.0–73.0])	0.419	8.2 (7.4–8.7), (65.5 [58.3–72.0])	8.1 (7.4–8.9), (65.0 [57.0–73.0])	0.838
GA, nM/ml	97.2 (73.9–117.8)	89.6 (76.3–115.9)	0.704	102.9 (73.9–125.3)	90.3 (76.3–115.2)	0.580	98.0 (82.6–113.7)	89.8 (74.0–117.8)	0.492
FA, mM/l	2.6 (2.4–2.9)	2.5 (2.3–3.0)	0.587	2.6 (2.4–2.9)	2.5 (2.3–3.0)	0.439	2.6 (2.4–3.0)	2.6 (2.4–3.0)	0.429
HbA1c-meanoverall, %, (mmol/mol)	8.3 ± 1.0, (67.4 ± 11.2)	8.0 ± 0.9, (64.2 ± 9.5)	0.141	8.3 ± 0.9, (67.2 ± 10.3)	8.1 ± 0.9, (64.7 ± 10.2)	0.280	8.2 ± 1.1, (66.4 ± 12.0)	8.1 ± 0.9, (65.1 ± 9.9)	0.787
HbA1c-SD, %	0.57 (0.42–0.78)	0.61 (0.44–0.81)	0.655	0.56 (0.42–0.76)	0.61 (0.44–0.82)	0.514	0.52 (0.39–0.97)	0.61 (0.46–0.81)	0.445
HbA1c-adjSD, %	0.55 (0.40–0.73)	0.58 (0.43–0.78)	0.771	0.53 (0.40–0.72)	0.58 (0.43–0.79)	0.577	0.51 (0.39–0.93)	0.57 (0.44–0.75)	0.480
HbA1c-CV, %	6.7 (5.5–8.7)	7.6 (5.7–9.9)	0.245	6.7 (5.5–8.5)	7.4 (5.7–10.1)	0.219	6.0 (5.0–11.5)	7.5 (5.8–9.5)	0.293
HbA1c-ARV	0.5 (0.4–0.6)	0.5 (0.3–0.7)	0.953	0.5 (0.4–0.6)	0.5 (0.4–0.6)	0.578	0.4 (0.4–0.6)	0.5 (0.4–0.7)	0.410

Data are median (interquartile range) or mean ± SD unless otherwise indicated. GA = glycated albumin, FA = fructosamine, SD = standard deviation, adjSD = adjusted standard deviation, CV = coefficient of variation, ARV = average real variability