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. 2022 Mar 11;12:4295. doi: 10.1038/s41598-022-08346-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of the expression of CTSB in gliomas of different WHO grades, isocitrate dehydrogenase (IDH) status, 1p/19q-codeleted status and O⁶-methylguanine-DNA methyltransferase (MGMT) promoter status. CTSB was significantly highly-expressed in high-grade gliomas (HGG), IDH-wildtype, 1p19q non- codeletion and MGMT promoter unmethylation gliomas in TCGA and CGGA datasets. The expression of CTSB in TCGA dataset according to WHO grade (A), IDH status (overall WHO grades (C), LGG (E), HGG(G)), 1p/19q-codeleted status (I) and MGMT status (K). The expression of CTSB in CGGA dataset according to WHO grades (B) and IDH status (overall WHO grades (D), LGG (F), HGG(H)), 1p/19q-codeleted status (J) and MGMT status (L). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.