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. 2022 Mar 11;12:4295. doi: 10.1038/s41598-022-08346-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CTSB-related inflammatory activities in gliomas. The relationship between CTSB and WHO grade, IDH status, molecular subtypes and inflammatory metagenes are presented as a heatmap in TCGA and CGGA databases (A,B). Correlograms showed the correlation between CTSB and inflammatory metagenes (C,D). Blue represents positive correlations, and red represents negative correlations. Color intensity and the size of the circle in pie charts are proportional to the correlation coefficients. The results indicated that CTSB was significantly positively correlated with most inflammatory activities.