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. 2022 Mar 11;12:4287. doi: 10.1038/s41598-022-08068-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Nicotinamide mononucleotide (NMN) improves the health of CSMN that become diseased due to TDP-43 pathology. (a) a representative image of CSMN from prpTDP-43^A315T-UeGFP mouse; (b) a representative image of CSMN from prpTDP-43^A315T-UeGFP mouse treated with 1 µM NMN; (c) a representative image of CSMN from WT-UeGFP mouse; (d) a representative image of CSMN from WT-UeGFP mouse treated with NMN. (e) Bar graph representation of average neurite length; (f) Percent distribution of axon length; and (g) Sholl analysis of arborization of neurites. Scale bar = 20 µm.