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. 2022 Mar 11;12:4287. doi: 10.1038/s41598-022-08068-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Correlative light electron microscopy shows improvement of mitochondrial ultrastructure upon NMN treatment. (a) a representative image of motor cortex neurons cultured on a gridded glass bottom 35 mm dish; boxed area enlarged to highlight presence of GFP expressing CSMN; (b) representative electron micrograph of an individual CSMN from prpTDP-43^A315T-UeGFP mouse showing mitochondrial ultrastructural defects, images of mitochondrion are enlarged to right; and (c) representative electron micrograph of an individual CSMN from prpTDP-43^A315T-UeGFP treated with 1 µM NMN showing improved mitochondrial ultrastructure, images of mitochondrion are enlarged to right. Scale bar = 1 µm.