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. 2022 Mar 11;13:1298. doi: 10.1038/s41467-022-29082-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, b In vitro NIR-II PA images of PMNS and PMNSG at different concentrations and the corresponding liner fits of NIR-II PA amplitude as a function of concentration at 1280 nm, respectively. c, d Time-dependent 3D-rendered NIR-II PA/US images of tumor sites after i.v. injection of PMNS and PMNSG and the corresponding quantification of PA amplitude as a function of time, respectively. Data are presented as mean ± SD. (n = 3). e Tomography images-depth resolved B-scan PA/US images of tumor regions after intravenous administration of PMNS and PMNSG. f Ex vivo 3D-rendered PA/US images of various organs. g Quantification of NIR-II PA amplitude in (f) (Data are presented as mean ± SD. n = 3). Source data are provided as a Source Data file.