Fig. 3. Structure basis for modulation of NaV1.3 by BLA.
a, b Cut-open sliced views of the NaV1.3 pore module shown in surface from top-down and side, respectively. c Space-filling of the open activation gate of NaVAb (PDB code: 5VB8) with BLA shown in spheres. d, e Binding of BLA physically blocks the contraction of NaV1.3 activation gate compared to the closed gate of resting state NaVAb (PDB code: 6P6W, colored in gray). Black arrows indicate shift of each S6 when transition to the closed resting state, and red bars indicate where the shifts are blocked. BLA is shown in a sphere model, and key residues for the selectivity filter are shown in sticks. f Structural comparison of the activation gate of NaV1.3 with the open state of NaVAb (PDB code: 5VB8, colored in light blue).