. 2022 Mar 11;12:4266. doi: 10.1038/s41598-022-07997-5

Table 4.

Genetic association with LDL-C response at primary index variants.

Discovery phenotype	Index variant	Beta (SE), p value*
Discovery phenotype	Index variant	Absolute LDL-C change	Fractional LDL-C change
ADA positive	AA_DRB1_120_32657518_N	0.011 (0.03), 0.74	− 0.019 (0.033), 0.58
	AA_DQB1_75_32740612	0.047 (0.0271),0.08	0.04592(0.0276), 0.10
	rs3093664	0.064 (0.045), 0.15	0.060 (0.045), 0.19
ADA max titer	rs7756741	0.039 (0.026), 0.13	0.045 (0.026), 0.08
ADA max titer	rs3763313	0.036 (0.027), 0.18	0.043 (0.027), 0.11

*From linear regression including covariates age, sex, smoking, study, and eigenvectors of population substructure. Units of SD after rank normal transformation of phenotype.