TABLE 1.

Comparison of the pharmacokinetic parameters of ampicillin^a (data from reference 19)

Parameter	Value (mean ± SD)
	Rabbit (n = 8)b	Human 2 g i.v.c	Rabbit humanlike (n = 7)d
t1/2 (h)	0.3 ± 0.03	1.1	0.99 ± 0.08
kel (h−1)	2.4 ± 0.29	0.63	0.71 ± 0.05
AUC0–α(μg · h/ml)	38.19	127.8	116.7 ± 31.83

^aThe pharmacokinetic parameters were estimated on the basis of an open one-compartment model. 

^bT_1/2 and k_el data are for healthy rabbits treated with 50 mg/kg i.v. The AUC_0–α was calculated from the data of an ideal profile obtained by C_0r of 80 μg/ml and the k_el of ampicillin in rabbits. 

^ck_el, t_1/2, and AUC_0–α were obtained from an ideal serum human profile of 2 g of i.v. ampicillin. 

^dData are for humanlike pharmacokinetics of 2 g of ampicillin in rabbits.