8. Vestergaard 2006: fracture and oral contraceptive use.
Age group (years) | Daily OC dosea | Cases (N) | Controls (N) | ORb (95% CI) |
< 25 | ‐ | 16,219 | 48,659 | ‐‐‐ |
< 0.3 | 331 | 795 | 0.97 (0.91 to 1.03) | |
0.3 to 0.99 | 1445 | 3872 | 0.96 (0.92 to 1.01) | |
> 1 | 1156 | 3546 | 0.92 (0.86 to 0.98) | |
25 to 49 | ‐ | 10,545 | 31,631 | ‐ |
< 0.3 | 1895 | 5491 | 0.91 (0.82 to 1.00) | |
0.3 to 0.99 | 2444 | 7445 | 0.90 (0.77 to 1.05) | |
> 1 | 783 | 2546 | 0.87 (0.64 to 1.18) | |
>50 | ‐ | 37,784 | 113,351 | ‐ |
< 0.3 | 799 | 2820 | 0.92 (0.77 to 1.10) | |
0.3 to 0.99 | 253 | 977 | 0.69 (0.45 to 1.05) | |
> 1 | 6 | 266 | 0.62 (0.27 to 1.41) |
aExposure as average daily dose, i.e., redeemed prescriptions/time interval from first prescription to fracture or censoring (Characteristics of included studies); < 1 indicates < regular use; > 1 suggests lost prescription and obtained new one. bAdjusted for Charlson index (19 comorbid conditions), ever use of corticosteroids, alcoholism, working or not, number of bed days in 1999, contacts with physician in 1999, income, living with someone or living alone, prior fracture, education level, pregnancy; use of anti‐epileptic drugs, thyroid active drugs (levothyroxine or antithyroid drugs), or hormone replacement therapy.