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. 2015 Jul 21;2015(7):CD009849. doi: 10.1002/14651858.CD009849.pub3

8. Vestergaard 2006: fracture and oral contraceptive use.

Age group (years) Daily OC dosea Cases (N) Controls (N) ORb (95% CI)
< 25  ‐ 16,219 48,659 ‐‐‐ 
  < 0.3 331 795 0.97 (0.91 to 1.03)
  0.3 to 0.99 1445 3872 0.96 (0.92 to 1.01)
  > 1 1156 3546 0.92 (0.86 to 0.98)
 
25 to 49 10,545 31,631 ‐ 
  < 0.3 1895 5491 0.91 (0.82 to 1.00)
  0.3 to 0.99 2444 7445 0.90 (0.77 to 1.05)
  > 1 783 2546 0.87 (0.64 to 1.18)
 
>50 37,784 113,351
  < 0.3 799 2820 0.92 (0.77 to 1.10)
  0.3 to 0.99 253 977 0.69 (0.45 to 1.05)
  > 1 266 0.62 (0.27 to 1.41)

aExposure as average daily dose, i.e., redeemed prescriptions/time interval from first prescription to fracture or censoring (Characteristics of included studies); < 1 indicates < regular use; > 1 suggests lost prescription and obtained new one.
 bAdjusted for Charlson index (19 comorbid conditions), ever use of corticosteroids, alcoholism, working or not, number of bed days in 1999, contacts with physician in 1999, income, living with someone or living alone, prior fracture, education level, pregnancy; use of anti‐epileptic drugs, thyroid active drugs (levothyroxine or antithyroid drugs), or hormone replacement therapy.