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. 2015 Jul 21;2015(7):CD009849. doi: 10.1002/14651858.CD009849.pub3

15. Vestergaard 2006 (2008b): fracture and hormonal IUD use.

  Subgroup Cases (N) Controls (N) OR (95% CI)a
Hormonal IUDb use ever  ‐  219 791 0.75 (0.64 to 0.87)
Age of woman (years)
 
 
< 25 3 5 0.82 (0.19 to 3.67)
25 to 50 187 639 0.87 (0.73 to 1.04)
> 50 29 147 0.72 (0.48 to 1.09)
 
IUDs per year
 
 
< 0.25 59 234 0.74 (0.55 to 1.00)
0.26 to 0.6 84 280 0.84 (0.65 to 1.08)
> 0.6 76 277 0.81 (0.62 to 1.05)
 
Duration of hormonal IUD use (years)
 
 
< 1.5 68 244 0.78 (0.59 to 1.03)
1.6 to 4 83 289 0.77 (0.59 to 0.99)
> 4 68 258 0.77 (0.58 to 1.01)

aAdjusted for prior fracture, Charlson index (comorbidities), income, working status, living with someone or not, pregnancy, DMPA use, hysterectomy, alcoholism; use of OC, corticosteroid, hormonal replacement therapy, anti‐epileptic drugs, and strong (morphine and opioid agonists) and weak analgesics (acetaminophen, nonsteroidal anti‐inflammatory drugs, and acetylsalicylic acid)
 bIUD = intrauterine device