Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 18;135(2):jcs258796. doi: 10.1242/jcs.258796

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

PMC Copyright notice

Fig. 3. — The arrhythmogenic N53I mutant causes subtle changes in the three-dimensional structure of Ca²⁺/CaM–RyR2_3583-3603. (A-C) Cartoon representation of the crystal structures of Ca²⁺/CaM proteins in complex with RyR2 peptide. (A) Ca²⁺/CaM-WT–RyR2_3583-3603 (PDB 6XXF). (B) Ca²⁺/CaM-N53I–RyR2_3583-3603 (PDB 6XY3). (C) Ca²⁺/CaM-A102V–RyR2_3583-3603 (PDB 6XXX). (D,E) Alignments of Ca²⁺/CaM-WT–RyR2_3583-3603 with Ca²⁺/CaM-N53I–RyR2_3583-3603 (D) or Ca²⁺/CaM-A102V–RyR2_3583-3603 (E) complex structures. Ca²⁺ ions are shown as orange spheres and water molecules as olive spheres. The WT and mutant residues are shown in stick representation. CaM-WT is displayed in beige, CaM-N53I in salmon, CaM-A102V in green and RyR2_3583-3603 peptide in blue. Images were generated using PyMOL software.