Table 1.

Multivariable Cox Analysis of Methylation Cluster and Known Prognostic Variables

Covariate		Univariable Cox		Multivariable Cox
		HR (95% CI)	P-value	HR (95% CI)	P-value
Methylation cluster	1 vs. 2	4.3 (1.4–13.4)	0.0119	14.2 (2.1–94.8)	0.0063
Age	Years	0.6 (0.3–1.2)	0.1413	0.7 (0.3–1.5)	0.3352
Location	Skull-base vs. spinal	2.5 (0.7–8.6)	0.1593	5.3 (0.6–45.2)	0.1292
Extent of resection	Subtotal vs. gross-total	1.8 (0.5–6.7)	0.3484	3.2 (0.4–24.0)	0.2674
Adjuvant radiotherapy	Not received vs. received	2.0 (0.7–5.9)	0.2303	13.9 (2.2–89.3)	0.0056
Time from initial treatment	Years	0.8 (0.4–1.3)	0.3177	0.8 (0.4–1.6)	0.5181

Abbreviations: CI, confidence interval; HR, hazard ratio.