Table 2.
Patients With Extracranial Diffuse Large B-Cell Lymphoma Involvement
| Patient | Age | Sex | Imaging for evaluation of the extent of disease | Positive imaging | Extracranial lymphoma involvement site | Treatment adjustment |
|---|---|---|---|---|---|---|
| Patient 1 | 38 | Male | Chest/abdomen/pelvis CT and whole-body PET/CT | Whole-body PET/CT | Sacrum | Rituximab, high dose methotrexate, vincristine, and procabarzine |
| Patient 2 | 83 | Female | Chest/abdomen/pelvis CT and whole-body PET/CT | Whole-body PET/CT | Upper arm | High dose methotrexate and R-CHOP |
| Patient 3 | 78 | Female | Chest/abdomen/pelvis CT and whole-body PET/CT | Abdominal/pelvic CT | Lymph node | Surgical resection |
| Patient 4 | 66 | Male | Chest/abdomen/pelvis CT and whole-body PET/CT | Abdominal/pelvic CT and whole-body PET/CT | Colon | High dose methotrexate and R-CHOP |
| Patient 5 | 59 | Male | Chest/abdomen/pelvis CT and whole-body PET/CT | Whole-body PET/CT | Lumbar spine pedicle | High dose methotrexate and cytarabine |
| Patient 6 | 70 | Female | Chest/abdomen/pelvis CT and whole-body PET/CT | Whole-body PET/CT | Gluteus maximus muscle | High dose methotrexate and cytarabine |
| Patient 7 | 75 | Male | Chest/abdomen/pelvis CT and whole-body PET/CT | Abdominal/pelvic CT and whole-body PET/CT | Adrenal gland | High dose methotrexate and R-CHOP |
| Patient 8 | 68 | Male | Chest/abdomen/pelvis CT and whole-body PET/CT | Abdominal/pelvic CT and whole-body PET/CT | Adrenal gland, spine, rib, iliac bone | High dose methotrexate and R-CHOP |
| Patient 9 | 66 | Female | Chest/abdomen/pelvis CT and whole-body PET/CT | Abdominal/pelvic CT and whole-body PET/CT | Lymph node | High dose methotrexate, vincristine, and procabarzine |
| Patient 10 | 46 | Female | Chest/abdomen/pelvis CT and whole-body PET/CT | Neck CT and whole-body PET/CT | Nasal cavity | High dose methotrexate, vincristine, and procabarzine |
| Patient 11 | 79 | Female | Chest/abdomen/pelvis CT and whole-body PET/CT | Whole-body PET/CT | Cheek, lymph node | Whole brain radiation therapy |
| Patient 12 | 49 | Male | Chest/abdomen/pelvis CT and whole-body PET/CT | Whole-body PET/CT | Nasal cavity, lymph node | High dose methotrexate and R-CHOP |
| Patient 13 | 64 | Female | Chest/abdomen/pelvis CT and whole-body PET/CT | Abdominal/pelvic CT and whole-body PET/CT | Adrenal gland | High dose methotrexate and R-CHOP |
| Patient 14 | 82 | Female | Whole-body PET/CT | Whole-body PET/CT | Nasopharynx | R-CHOP |
| Patient 15 | 79 | Female | Chest/abdomen/pelvis CT and whole-body PET/CT | Chest CT and whole-body PET/CT | Heart, lymph node | R-CHOP |
| Patient 16 | 71 | Male | Chest/abdomen/pelvis CT and whole-body PET/CT | Chest/abdomen/pelvis CT or whole-body PET/CT | Adrenal gland, lymph node | R-CHOP |
| Patient 17 | 74 | Male | Chest/abdomen/pelvis CT and whole-body PET/CT | Neck CT and whole-body PET/CT | Lymph node | High dose methotrexate, vincristine, and dexamethasone |
| Patient 18 | 77 | Male | Chest/abdomen/pelvis CT and whole-body PET/CT | Abdominal/pelvic CT and whole-body PET/CT | Adrenal gland | High dose methotrexate, vincristine, and dexamethasone |
| Patient 19 | 65 | Male | Chest/abdomen/pelvis CT and whole-body PET/CT | Abdominal/pelvic CT and whole-body PET/CT | Acetabulum | High dose methotrexate, ifosfamide, etoposide, and cytarabine |
| Patient 20 | 20 | Male | Chest/abdomen/pelvis CT | Chest/abdomen/pelvis CT | Whole brain radiation therapy and rituximab | |
| Patient 21 | 57 | Female | Chest/abdomen/pelvis CT and whole-body PET/CT | Abdominal/pelvic CT and whole-body PET/CT | Adrenal gland | High dose methotrexate and R-CHOP |
| Patient 22 | 70 | Female | Chest/abdomen/pelvis CT and whole-body PET/CT | Abdominal/pelvic CT and whole-body PET/CT | Lymph node | High dose methotrexate and rituximab |
| Patient 23 | 74 | Female | Chest/abdomen/pelvis CT and whole-body PET/CT | Chest/abdomen/pelvis CT | Lymph node | High dose methotrexate |
| Patient 24 | 68 | Male | Chest/abdomen/pelvis CT and whole-body PET/CT | Whole-body PET/CT | Adrenal gland | High dose methotrexate and R-CHOP |
| Patient 25 | 80 | Female | Chest/abdomen/pelvis CT and whole-body PET/CT | Abdominal/pelvic CT and whole-body PET/CT | Retroperitoneum | High dose methotrexate and R-CHOP |
| Patient 26 | 68 | Female | Chest/abdomen/pelvis CT and whole-body PET/CT | Chest CT and whole-body PET/CT | Lymph node | High dose methotrexate and R-CHOP |
| Patient 27 | 80 | Male | Chest/abdomen/pelvis CT and whole-body PET/CT | Abdominal/pelvic CT and whole-body PET/CT | Liver | High dose methotrexate and R-CHOP |
Abbreviations: CNS, central nervous system; CT, computed tomography; PET, positron emission tomography; R-CHOP, rituximab cyclophosphamide doxorubicin vincristine prednisone.