Table 4.
Comparison of Contrast-Enhanced Chest/Abdomen/Pelvis CT and Whole-Body PET/CT for Detection of Extracranial Lymphoma Involvement in Patients With a Positive Diagnosis of Primary CNS DLBCL
| Outcome | Contrast-Enhanced Chest/Abdomen/Pelvis CT (n = 920) |
Whole-Body PET/CT (n = 854) |
Both Contrast-Enhanced Chest/Abdomen/Pelvis CT and whole-body PET/CT (n = 733) | P valuea | P valueb | P valuec |
|---|---|---|---|---|---|---|
| True-positive | 26 of 920 (2.8%; 95% CI, 1.9–4.1%) |
26 of 854 (3.0%; 95% CI, 2.0–4.4%) |
25 of 733 (3.4%; 95% CI, 2.2–5.0%) |
.802 | .482 | .651 |
| False-positive | 49 of 920 (5.3%; 95% CI, 4.0–7.0%) |
57 of 854 (6.7%; 95% CI, 5.1–8.6%) |
46 of 733 (6.3%; 95% CI, 4.6–8.3%) |
.214 | .386 | .748 |
| Patients >61 years old | ||||||
| True-positive | 20 of 455 (4.4%; 95% CI, 2.7–6.7%) |
21 of 435 (4.8%; 95% CI, 3.0–7.3%) |
20 of 367 (5.5%; 95% CI, 3.4–8.3%) |
.776 | .468 | .654 |
| False-positive | 25 of 455 (5.5%; 95% CI, 3.6–8.0%) |
27 of 435 (6.2%; 95% CI, 4.1–8.9%) |
25 of 367 (6.8%; 95% CI, 4.5–9.9%) |
.656 | .438 | .731 |
| Patients ≤61 years old | ||||||
| True-positive | 6 of 465 (1.3%; 95% CI, 0.5–2.8%) |
5 of 419 (1.2%; 95% CI, 0.4–2.8%) |
5 of 366 (1.4%; 95% CI, 0.5–3.2%) |
.894 | .901 | .805 |
| False-positive | 24 of 465 (5.2%; 95% CI, 3.3–7.6%) |
30 of 419 (7.2%; 95% CI, 4.9–10.1%) |
21 of 366 (5.7%; 95% CI, 3.6–8.6%) |
.217 | .752 | .395 |
Abbreviations: CNS, central nervous system; CT, computed tomography; DLBCL, diffuse large B-cell lymphoma; PET, positron emission tomography; SD, standard deviation.
a P values between CT and PET/CT.
b P values between CT and both CT and PET/CT.
c P values between PET/CT and both CT and PET/CT.