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. 2021 Jul 7;24(3):384–395. doi: 10.1093/neuonc/noab162

Fig. 3.

Fig. 3

Lisavanbulin combined with six-week radiation regimens significantly improves overall survival (A-C). Mice with the indicated orthotopic PDXs were randomized and treated 14 days after tumor implantation. Mice were dosed with vehicle, RT, or RT + lisavanbulin (LIS). RT was given in 2 Gy fractions either Monday through Friday for 2 weeks or Monday, Wednesday, and Friday for 6 weeks. LIS dosing was limited to the RT window.