Fig.4.

Lisavanbulin addition to RT/TMZ-TMZ significantly extends survival in responsive PDX model (A-C). Mice with the indicated orthotopic PDXs were randomized and treated approximately 14 days after tumor implantation. Mice were dosed with vehicle, lisavanbulin (LIS), RT/TMZ-TMZ, or RT/TMZ-TMZ + LIS. RT was given in 2 Gy fractions Monday through Friday for 2 weeks concurrently with 20 mg/kg TMZ. Adjuvant TMZ (50 mg/kg) was given days 1-5 every 28 days for three cycles while LIS dosing was continued Monday through Sunday until moribund.