Table 3.
Analysis of KEGG pathway enrichment using the XF-CRS network (top 20 with count).
| Pathway | Enrichment score | P value | Count | Genes |
|---|---|---|---|---|
| Inflammatory bowel disease (IBD) | 9.884173094 | 3.08E − 16 | 17 | IL-10, JUN, TGFB1, SMAD3, STAT1, IL-13, STAT3, TNF, IL-2, RELA, NFKB1, IL-4, IL-6, IFNG, IL-1B, TLR4, IL-17 A |
| HIF-1 signaling pathway | 3.721318074 | 8.99E − 16 | 19 | NOS2, NOS3, EGF, STAT3, PRKCA, IGF1, HIF1A, EGFR, RELA, NFKB1, INS, VEGFA, IL-6, IFNG, BCL2, AKT1, HMOX1, TLR4, MAPK3 |
| Chagas disease (American trypanosomiasis) | 9.884173094 | 4.18E − 15 | 19 | IL-10, JUN, TGFB1, CXCL8, SMAD3, NOS2, TNF, IL-2, RELA, NFKB1, IL-6, MAPK8, IFNG, IL-1B, CCL5, CCL2, AKT1, TLR4, MAPK3 |
| Influenza A | 9.884173094 | 3.59E − 13 | 21 | PRSS1, JUN, CXCL8, IFNA1, STAT1, PRKCA, PLG, TNF, RELA, NFKB1, ICAM1, IL-6, MAPK8, IFNG, IL-1B, CCL5, CCL2, AKT1, NLRP3, TLR4, MAPK3 |
| Leishmaniasis | 9.884173094 | 9.03E − 13 | 15 | IL-10, JUN, TGFB1, ITGAM, NOS2, STAT1, PTGS2, TNF, RELA, NFKB1, IL-4, IFNG, IL-1B, TLR4, MAPK3 |
| Amoebiasis | 9.884173094 | 1.47E − 12 | 17 | IL-10, ARG2, TGFB1, ITGAM, CXCL8, CSF2, NOS2, HSPB1, PRKCA, TNF, RELA, NFKB1, IL-6, IFNG, IL-1B, CASP3, TLR4 |
| TNF signaling pathway | 9.884173094 | 1.71E – 12 | 17 | JUN, VCAM1, CSF2, PTGS2, TNF, MMP9, RELA, NFKB1, ICAM1, IL-6, MAPK8, IL-1B, CASP3, CCL5, CCL2, AKT1, MAPK3 |
| Pertussis | 9.884173094 | 2.01E − 12 | 15 | IL-10, JUN, ITGAM, CXCL8, NOS2, TNF, RELA, NFKB1, IL-6, MAPK8, IL-1B, CASP3, NLRP3, TLR4, MAPK3 |
| Toxoplasmosis | 9.884173094 | 2.66E − 12 | 17 | IL-10, TGFB1, NOS2, STAT1, STAT3, TNF, RELA, NFKB1, MAPK8, CD40LG, IFNG, CASP3, ALOX5, BCL2, AKT1, TLR4, MAPK3 |
| Tuberculosis | 9.884173094 | 5.19E − 12 | 20 | IL-10, TGFB1, ITGAM, NOS2, IFNA1, STAT1, SRC, TNF, RELA, NFKB1, IL-6, MAPK8, IFNG, IL-1B, CASP3, BCL2, BAX, AKT1, TLR4, MAPK3 |
| Toll-like receptor signaling pathway | 9.884173094 | 2.62E − 10 | 15 | JUN, CXCL8, IFNA1, STAT1, CD80, TNF, RELA, NFKB1, IL-6, MAPK8, IL-1B, CCL5, AKT1, TLR4, MAPK3 |
| NOD-like receptor signaling pathway | 9.884173094 | 3.03E − 10 | 12 | IL-6, HSP90AA1, MAPK8, CXCL8, CCL5, IL-1B, NLRP3, CCL2, TNF, RELA, NFKB1, MAPK3 |
| Pancreatic cancer | 3.592461238 | 1.64E − 09 | 12 | MAPK8, TGFB1, SMAD3, STAT1, EGF, STAT3, AKT1, RELA, EGFR, NFKB1, MAPK3, VEGFA |
| Salmonella infection | 9.884173094 | 2.38E − 08 | 12 | IL-6, JUN, MAPK8, CXCL8, CSF2, IFNG, NOS2, IL-1B, TLR4, RELA, NFKB1, MAPK3 |
| Non-alcoholic fatty liver disease (NAFLD) | 9.884173094 | 2.87E − 08 | 15 | XBP1, JUN, TGFB1, CXCL8, TNF, RELA, NFKB1, INS, ERN1, IL-6, MAPK8, IL-1B, CASP3, BAX, AKT1 |
| Legionellosis | 9.884173094 | 6.24E − 08 | 10 | IL-6, VCP, ITGAM, CXCL8, IL-1B, CASP3, TNF, TLR4, RELA, NFKB1 |
| PI3K-Akt signaling pathway | 3.721318074 | 7.90E − 08 | 21 | CSF3, HSP90AA1, IFNA1, NOS3, EGF, PRKCA, IGF1, EGFR, IL-2, RELA, NFKB1, INS, VEGFA, IL-4, IL-3, FGF7, IL-6, BCL2, AKT1, TLR4, MAPK3 |
| Osteoclast differentiation | 3.592461238 | 3.47E − 07 | 13 | JUN, TGFB1, STAT1, TNF, RELA, NFKB1, MAPK8, IFNG, IL-1B, BTK, AKT1, PPARG, MAPK3 |
| Prostate cancer | 3.721318074 | 4.72E − 07 | 11 | HSP90AA1, EGF, BCL2, CTNNB1, AKT1, IGF1, RELA, EGFR, NFKB1, MAPK3, INS |
| Hepatitis C | 3.592461238 | 3.05E − 06 | 12 | MAPK8, CXCL8, IFNA1, STAT1, EGF, STAT3, AKT1, TNF, RELA, EGFR, NFKB1, MAPK3 |