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. 2022 Jan 24;149(8):dev200139. doi: 10.1242/dev.200139

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© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — Fetal HSCs reconstitute TLCs with greater efficiency compared with adult HSCs. (A) Schematic of experimental design: 250 fetal HSCs and 250 adult HSCs from different fluorescent mice (KuO and UBC-GFP, respectively) were co-transplanted into sublethally irradiated WT recipients and donor contribution to hematopoietic cells was quantified in several organs 16 weeks post-transplantation. (B) Donor chimerism of TLCs was significantly greater by fetal HSCs compared with adult HSCs. Quantification of donor chimerism of peritoneal B1a cells, splenic MZBs, and lung ILC2s and Tregs. (C) Fetal and adult HSCs engrafted in the BM with similar efficiencies, but donor chimerism of fetal-derived CLPs was significantly greater than adult-derived CLPs. Quantification of donor chimerism of fetal and adult HSC, CMP and CLP in recipient BM. Fetal HSC n=4, adult HSC n=4, two independent experiments. Differences were analyzed with unpaired two-tailed Student's t-test: ****P<0.0001. n.s., not significant.