Table 6.
Unadjusted and adjusted risk of clinical failure
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| p value | Unadjusted HR (95% CI) | p value | Adjusted HR (95% CI) | |
| Sex (male vs female) | 0.420 | 1.248 (0.728–2.139) | ||
| Age (per year increase) | 0.001 | 1.032 (1.013–1.051) | 0.140 | 1.014 (0.995–1.034) |
| BMI (per point increase) | 0.005 | 1.111 (1.032–1.197) | 0.043 | 1.096 (1.003–1.198) |
| Treatment (SVF vs HA) | < 0.001 | 3.067 (1.849–5.089) | < 0.001 | 3.602 (2.116–6.131) |
| KL grade (2 vs 3) | < 0.001 | 1.718 (1.277–2.311) | 0.218 | 1.277 (0.865–1.885) |
| Mechanical axis (per degree increase) | 0.068 | 1.101 (0.993–1.221) | 0.689 | 1.023 (0.917–1.141) |
| Full-thickness cartilage defect (per grade increase) | 0.002 | 1.581 (1.177–2.123) | 0.403 | 1.158 (0.821–1.634) |
| Total cartilage volume (per mm3 increase) | 0.018 | 1.000 (1.000–1.000) | 0.919 | 1.000 (1.000–1.000) |
| BML size (per mm2 increase) | < 0.001 | 1.002 (1.001–1.003) | 0.627 | 1.000 (0.999–1.002) |
| BML severity (per point increase) | < 0.001 | 1.154 (1.093–1.219) | 0.024 | 1.104 (1.013–1.202) |
| Patella-femoral pathology | 0.310 | 1.263 (0.805–1.981) | 0.873 | 0.960 (0.578–1.592) |
HR, hazard ratio; CI, confidence interval; BMI, Body mass index; KL, Kellgren–Lawrence; BML, bone marrow lesion