Table 3.
Multivariate logistic regression analyses of serum EV ARG 1 levels and different duration of T2DM
| EV ARG 1 (per 10 pg/mL increase) | No. of patients | Unadjusted | Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | P value | OR (95%CI) | P value | OR (95%CI) | P value | OR (95%CI) | P value | ||
| Total | 103 | 1.318 (1.165–1.492) | < 0.001 | 1.376 (1.194–1.585) | < 0.001 | 1.450 (1.135–1.851) | 0.003 | 1.388 (1.155–1.669) | < 0.001 |
| Non-T2DM (Reference) | 18 | 1.000 | – | 1.000 | – | 1.000 | – | 1.000 | – |
| Prediabetes | 12 | 0.857 (0.711–1.034) | 0.107 | 0.880 (0.729–1.063) | 0.184 | 0.889 (0.694–1.139) | 0.239 | 0.897 (0.696–1.157) | 0.831 |
| < 4, years | 24 | 1.177 (1.007–1.374) | 0.040 | 1.220 (1.025–1.453) | 0.025 | 1.230 (1.014–1.492) | 0.036 | 1.194 (1.001–1.424) | 0.048 |
| 4–10, years | 26 | 1.213 (1.051–1.400) | 0.008 | 1.417 (1.065–1.886) | 0.017 | 1.400 (1.071–1.829) | 0.014 | 1.425 (1.098–1.850) | 0.008 |
| > 10, years | 23 | 1.386 (1.101–1.743) | 0.005 | 1.488 (1.109–1.997) | 0.008 | 1.734 (1.040–2.890) | 0.035 | 1.651 (1.066–2.557) | 0.025 |
EV Extracellular vesicles, T2DM Type 2 diabetes mellitus, ARG 1 Arginase 1, SBP Systolic blood pressure, BMI Body Mass Index, TG Triglyceride, LDL-C Low-density lipoprotein cholesterol, HDL-C High-density lipoprotein cholesterol, hs-CRP High-sensitivity C-reactive protein, OR Odds Ratio, CI Confidence Interval
Model 1: adjusted for age, sex, and BMI;
Model 2: adjusted for Model 1 + smoke, drink, SBP, TC, TG, hs-CRP
Model 3: adjusted for Model 2 + coronary heart disease
*p < 0.05, **p < 0.001