Table 4.
Association of serum EV ARG 1 with diabetic medication and newly diagnosed T2DM in fully adjusted models
| EV ARG 1 (per 10 pg/mL increase) | Newly diagnosed T2DM (n = 45) | T2DM with diabetic medication (n = 28) | ||
|---|---|---|---|---|
| OR (95%CI) | P value | OR (95%CI) | P value | |
| Unadjusted | 1.257 (1.110–1.422) | < 0.001** | 1.366 (1.147–1.628) | < 0.001** |
| Model 1 | 1.290 (1.124–1.480) | < 0.001** | 1.490 (1.201–1.849) | < 0.001** |
| Model 2 | 1.272 (1.086–1.490) | 0.003* | 1.563 (1.160–2.106) | 0.003* |
| Model 3 | 1.335 (1.096–1.625) | 0.004* | 1.635 (1.139–2.347) | 0.008* |
EV Extracellular vesicles, T2DM Type 2 diabetes mellitus, ARG 1 Arginase 1, SBP Systolic blood pressure, BMI Body Mass Index, TG Triglyceride, TC Total cholesterol, hs-CRP High-sensitivity C-reactive protein, OR Odds Ratio, CI Confidence Interval
Model 1: adjusted for age, sex, BMI;
Model 2: adjusted for Model 1 + age, sex, BMI, SBP, smoking, drinking, TC, hs-CRP and TG
Model 3: adjusted for Model 2 + coronary heart disease
*p < 0.05, **p < 0.001