Table 3.
KEGG 2019 and Reactome 2016 resulting pathways that were common between the three tissues
| Database | iPSC-derived neurons and FCLs and LCLs | iPSC-derived neurons and FCLs | iPSC-derived neurons and LCLs | FCLs and LCLs |
|---|---|---|---|---|
| KEGG 2019 | Proteoglycans in cancer | Melanoma | Salmonella infection | |
| Malaria | ||||
| C-type lectin receptor signaling pathway | ||||
| Chagas disease (American trypanosomiasis) | ||||
| Legionellosis | ||||
| Amoebiasis | ||||
| Hematopoietic cell lineage | ||||
| Cytokine-cytokine receptor interaction | ||||
| Axon guidance | ||||
| Reactome 2016 | Cytokine signaling in immune system | Defective CHST6 causes MCDC1 | Interferon alpha/beta signaling | Termination of translesion DNA synthesis |
| Defective ST3GAL3 causes MCT12 and EIEE15 | DNA Damage Bypass | |||
| Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | Gap-filling DNA repair synthesis and ligation in GG-NER | |||
| Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | Growth hormone receptor signaling | |||
| Non-integrin membrane-ECM interactions | Nicotinate metabolism | |||
| Keratan sulfate degradation | Signaling by Interleukins | |||
| Extracellular matrix organization | Recognition of DNA damage by PCNA-containing replication complex | |||
| Diseases associated with glycosaminoglycan metabolism | Immune system | Rho GTPase cycle | ||
| HS-GAG biosynthesis | ||||
| Glycosaminoglycan metabolism | Senescence-Associated Secretory Phenotype (SASP) | |||
| Heparan sulfate/heparin (HS-GAG) metabolism | ||||
| ECM proteoglycans | Axon guidance | |||
| Cell surface interactions at the vascular wall |