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. Author manuscript; available in PMC: 2022 Mar 12.
Published in final edited form as: Nat Protoc. 2021 Jun 14;16(7):3348–3381. doi: 10.1038/s41596-021-00540-2

Figure 1.

Figure 1.

In vivo pretargeting based on the inverse electron demand Diels-Alder reaction. (A) The inverse electron demand Diels-Alder (IEDDA) ligation between 1,2,4,5-tetrazine and trans-cyclooctene; (B) Schematic of in vivo pretargeting based on the inverse electron demand Diels-Alder reaction. Adapted with permission from Membreno, R., Cook, B. E., Fung, K., Lewis, J. S. & Zeglis, B. M. Click-mediated pretargeted radioimmunotherapy of colorectal carcinoma. Mol Pharm 15, 1729-1734, (2018). Copyright 2018 American Chemical Society.

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