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Several ligation mechanisms have been leveraged to facilitate in vivo pretargeting: (A) the inverse electron demand Diels-Alder reaction; (B) the interaction between streptavidin and biotin; (C) the ability of bispecific antibodies to bind both a cancer antigen and a hapten; (D) the hybridization of complementary oligonucleotides; (E) the Staudinger ligation; (F) the strain-promoted azide-alkyne click reaction; and (G) the host-guest relationship between adamantane and cucurbituril.
