Figure 7.

Representative pretargeted PET images using [⁶⁴Cu]Cu-SarAr-Tz and huA33-TCO with 24 h (A) 48 h (B), and 120 h (C) interval times between the two injections. (D) Biodistribution data for in vivo pretargeting with huA33-TCO and [⁶⁴Cu]Cu-SarAr-Tz in athymic nude mice bearing subcutaneous SW1222 human colorectal cancer xenografts (n = 4) using pretargeting intervals of 24 (red), 48 (blue), or 120 (grey) h. At each interval, mice were sacrificed at 4, 12, and 24 hours after the administration of the radioligand. Reprinted with permission from Zeglis, B. M. et al. Optimization of a pretargeted strategy for the PET imaging of colorectal carcinoma via the modulation of radioligand pharmacokinetics. Mol Pharm 12, 3575-3587, (2015). Copyright 2015 American Chemical Society.