Table 6.
Association between the TyG index and the risk of carotid artery plaques according to different glucose regulation state and sex
| Sex | Glucose regulation state | Variables | Carotid artery plaques | |||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI)a | P-value | OR (95% CI)b | P-value | OR (95% CI)c | P-value | |||
| Male | Normal glucose regulation | TyG index | 0.88 (0.81–0.96) | 0.005 | 1.24 (1.13–1.36) | < 0.001 | 1.21 (1.06–1.39) | 0.005 |
| Q1 | Reference | Reference | Reference | |||||
| Q2 | 0.98 (0.88–1.10) | 0.751 | 1.23 (1.09–1.38) | 0.001 | 1.06 (0.93–1.21) | 0.398 | ||
| Q3 | 0.79 (0.69–0.90) | < 0.001 | 1.10 (0.96–1.27) | 0.182 | 0.83 (0.70–0.96) | 0.033 | ||
| Q4 | 0.57 (0.48–0.68) | < 0.001 | 1.00 (0.82–1.22) | 0.974 | 0.91 (0.69–1.19) | 0.494 | ||
| Prediabetes | TyG index | 0.67 (0.61–0.74) | < 0.001 | 0.97 (0.87–1.07) | 0.505 | 0.95 (0.82–1.12) | 0.557 | |
| Q1 | Reference | Reference | Reference | |||||
| Q2 | 0.94 (0.81–1.10) | 0.420 | 1.05 (0.89–1.24) | 0.552 | 0.94 (0.79–1.12) | 0.511 | ||
| Q3 | 0.85 (0.73–0.99) | 0.038 | 1.18 (1.00–1.39) | 0.055 | 1.02 (0.84–1.23) | 0.846 | ||
| Q4 | 0.49 (0.42–0.58) | < 0.001 | 0.83 (0.69–1.00) | 0.045 | 0.67 (0.52–0.86) | 0.002 | ||
| Diabetes | TyG index | 0.91 (0.84–0.97) | 0.005 | 1.11 (1.03–1.19) | 0.009 | 1.23 (1.10–1.37) | < 0.001 | |
| Q1 | Reference | Reference | Reference | |||||
| Q2 | 0.99 (0.78–1.24) | 0.904 | 1.19 (0.94–1.51) | 0.143 | 1.13 (0.88–1.45) | 0.331 | ||
| Q3 | 1.06 (0.85–1.32) | 0.592 | 1.34 (1.07–1.67) | 0.011 | 1.13 (0.90–1.44) | 0.284 | ||
| Q4 | 0.98 (0.79–1.20) | 0.821 | 1.48 (1.19–1.84) | < 0.001 | 1.37 (1.08–1.74) | 0.010 | ||
| Female | Normal glucose regulation | TyG index | 1.05 (0.97–1.14) | 0.198 | 1.09 (1.00–1.19) | 0.046 | 1.02 (0.90–1.15) | 0.794 |
| Q1 | Reference | Reference | Reference | |||||
| Q2 | 1.06 (0.97–1.15) | 0.223 | 1.04 (0.94–1.14) | 0.469 | 1.01 (0.91–1.23) | 0.825 | ||
| Q3 | 1.17 (1.06–1.30) | 0.003 | 1.22 (1.09–1.37) | 0.001 | 1.16 (1.01–1.33) | 0.043 | ||
| Q4 | 1.03 (0.86–1.24) | 0.739 | 1.23 (1.01–1.5) | 0.041 | 1.22 (0.95–1.56) | 0.115 | ||
| Prediabetes | TyG index | 1.05 (0.97–1.14) | 0.244 | 1.14 (1.04–1.24) | 0.005 | 1.17 (1.02–1.35) | 0.023 | |
| Q1 | Reference | Reference | Reference | |||||
| Q2 | 0.94 (0.84–1.06) | 0.327 | 1.05 (0.93–1.20) | 0.410 | 0.93 (0.81–1.07) | 0.336 | ||
| Q3 | 1.22 (1.08–1.38) | 0.001 | 1.26 (1.11–1.44) | < 0.001 | 1.10 (0.94–1.29) | 0.222 | ||
| Q4 | 0.89 (0.77–1.03) | 0.127 | 1.12 (0.96–1.31) | 0.145 | 1.12 (0.89–1.40) | 0.328 | ||
| Diabetes | TyG index | 1.44 (1.35–1.53) | < 0.001 | 1.58 (1.48–1.69) | < 0.001 | 1.45 (1.32–1.60) | < 0.001 | |
| Q1 | Reference | Reference | Reference | |||||
| Q2 | 1.31 (1.08–1.59) | 0.005 | 1.30 (1.06–1.59) | 0.012 | 1.14 (0.91–1.42) | 0.261 | ||
| Q3 | 1.44 (1.21–1.73) | < 0.001 | 1.38 (1.14–1.67) | 0.001 | 1.01 (0.82–1.25) | 0.930 | ||
| Q4 | 1.97 (1.65–2.34) | < 0.001 | 2.15 (1.78–2.58) | < 0.001 | 1.42 (1.14–1.77) | 0.002 | ||
aModel 1: unadjusted
bModel 2: adjusted for age, SBP, DBP
cModel 3: adjusted for age, SBP, DBP, CRP, TC, HDL-C, LDL-C, smoking, drinking, hypertension, hyperlipidemia, use of antihypertensives, and use of antilipidemic