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. 2022 Mar 12;22:177. doi: 10.1186/s12888-022-03824-3

Table 3.

Sociodemographic and Health-related Characteristics of Participants in the Four Loneliness and Isolated Living Status Groups

aNeither Lonely, nor Isolated (N=438) bNot Lonely,
but Isolated
(N=100)
cLonely,
but Not Isolated
(N=49)
dLonely and Isolated
(N=42)
F or χ2 Pairwise comparisons
among means
Age 65.0±7.2 69.2±7.0 66.2±7.1 69.1±6.8 12.2*** a<b, a<d
Sex 30.5***
 Male 287(65.5) 39(39) 27(55.1) 17(40.5)
 Female 151(34.5) 61(61) 22(44.9) 25(59.5)
Education 20.8
 No schooling 97(22.2) 29(29) 20(40.8) 16(38.1)
 Elementary (<6 years) 195(44.5) 46(46) 17(34.7) 20(47.6)
 Junior High (7-9 years) 53(12.1) 10(10) 2(4.1) 3(7.1)
 Senior High (9-12 years) 50(11.4) 11(11) 6(12.2) 2(4.8)
 College (>12 years) 43(9.8) 4(4) 4(8.2) 1(2.4)
Comorbidity+ 0.8±0.9 0.9±1.0 1.1±1.1 1.2±1.2 4.3*** a<d
Loneliness2006
 Yes 43(9.8) 17(17.0) 10(20.4) 17(40.5)
 No 395(90.2) 83(83.0) 39(79.6) 25(59.5)
Isolated living status2006
 Yes 39(8.9) 99(99.0) 10(20.4) 41(97.6)
 No 399(91.1) 1(1.0) 39(79.6) 1(2.4)
Perceived Stress Scale 8.6±5.9 8.6±6.9 13.4±7.1 11.5±7.7 9.1*** b<c, d<c
Stress-related Biomarkers
 Cortisol levels2000 21.2±20.4 16.6±13.3 18.3±10.6 12.7±7.9 4.2** a>d
 Cortisol levels2006 11.9±15.7 9.2±13.2 21.1±26.7 10.1±23.6 4.2** a<c, b<c
 IL-6 levels2000 2.9±3.3 2.9±2.4 2.7±2.7 3.7±4.7 0.8
 IL-6 levels2006 3.7±5.3 3.9±4.3 6.6±11.2 5.1±7.4 3.5* a<c
 hsCRP2000 - - - - - -
 hsCRP2006 0.3±0.5 0.3±0.5 0.8±1.6 0.3±0.3 7.67*** a<c, b<c, d<c
Depression#
  CES-D2000 3.8±4.0 4.3±3.8 10.5±6.1 9.2±6.0 51.4*** a<c, a<d, b<c, b<d
  CES-D2006 4.3±4.7 5.4±5.5 6.6±5.4 8.5±7.1 11.0*** a<c<d, b<d
Disability
 Mobility2000 2.0±3.4 3.7±4.3 5.3±6.0 5.3±5.5 20.3*** a<b, a<c<d
 Mobility2006 4.3±5.6 6.7±6.7 6.3±7.0 8.3±7.3 9.6*** a<b, a<d
 IADLs2000 0.4±1.5 1.0±2.1 1.5±2.6 1.4±2.1 10.8*** a<b, a<c, a<d
 IADLs2006 1.6±3.2 2.9±4.4 2.5±4.4 3.5±4.3 7.0** a<b, a<d

Note. Numbers are Mean±SD or N (%). CES-D The Center for Epidemiologic Studies Depression Scale; IADLs Instrumental Activities of Daily Living; IL-6 Interleukin-6; hsCRP High sensitivity C-reactive protein. +total 9-item comorbidity score. #9-item CES-D score (excluding lonely). *p < 0.05; **p < 0.01; *** p < 0.001