Table 3.

Haematological changes between days 0 and 7 based on CYP2D6 and G6PD status

Haematological changes based on CYP2D6 status
A: absolute haemoglobin reduction
Day of follow-up	Reduced CYP2D6	Normal CYP2D6	Statistical test
	Mean (95%CI)	Mean (95%CI)
Day 1	0.86 (0.50–1.22)	0.67 (0.49–0.86)	t = 1.034, p = 0.303
Day 2	1.28 (0.89–1.65)	1.21 (1.01–1.42)	t = 0.383, p = 0.703
Day 3	1.50 (1.10–1.90)	1.51 (1.31–1.71)	t = 0.012 p = 0.990
Day 7	1.16 (0.70–1.62)	1.05 (0.79–1.28)	t = 0.428, p = 0.669

B: relative % haemoglobin reduction
Day of follow-up
Day 1	7.65 (4.24–10.62)	6.12 (4.16–7.55)	t = 0.834, p = 0.406
Day 2	11.15 (7.84–14.13)	11.02 (8.97–12.64)	t = 0.069, p = 0.945
Day 3	13.12 (9.51–16.44)	13.80 (11.81–15.43)	t = − 0.347, p = 0.729
Day 7	9.82 (5.96–13.68)	9.19 (6.86–11.30)	t = 0.270, p = 0.788

Haematological changes based on G6PD status
A: mean absolute haemoglobin reduction
Day of follow-up	G6PD deficient, mean (95%CI)	G6PD Normal, mean (95%CI)	G6PD Heterozygous mean (95%CI)	Statistical Test
Day 1	0.94 (0.52–1.35)	0.69 (0.52–0.88)	0.72 (0.16–1.29)	F = 0.463, p = 0.630
Day 2	1.27 (0.83–1.71)	1.24 (1.03–1.45)	1.19 (0.66–1.72)	F = 0.028, p = 0.972
Day 3	1.82 (1.32–2.32)	1.48 (1.30–1.67)	1.47 (0.76–2.18)	F = 0.838, p = 0.435
Day 7	1.55 (1.02–2.08)	1.05 (0.82–1.28)	0.75 (− 0.04 to 1.53)	F = 2.063, p = 0.131

B: mean relative % haemoglobin reduction
Day of follow-up
Day 1	8.35 (4.58–12.12)	6.12 (4.44–7.81)	6.43 (1.20–11.66)	F = 0.438, p = 0.618
Day 2	11.13 (7.28–14.98)	11.07 (9.25–12.89)	10.82 (5.90–15.73)	F = 0.007, p = 0.993
Day 3	16.46 (12.0–20.92)	13.27 (11.63–14.9)	13.10 (6.39–19.81)	F = 0.928, p = 0.398
Day 7	13.57 (9.39–17.75)	9.06 (6.95–11.17)	6.57 (− 0.87 to 14.01)	F = 1.896, p = 0.154

t T-test, F ANOVA